Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints
Maria Gabriella Raimondo, Hashem Mohammadian, Mario Raphael Angeli, Stefano Alivernini, Vladyslav Fedorchenko, Kaiyue Huang, Richard Demmler, Peter Rhein, Cong Xu, Yinan Li, Raphael Micheroli, Zoltán Winter, Aleix Rius Rigau, Charles Gwellem Anchang, Alina Soare, , Andreas Ramming
The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.
bioRxiv · Aug 14, 2025 · PreprintImmunology