Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Patrick B. Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J Apiz Saab, Kelly H Sokol, Vin‐Cent Wu, Deepa Kumari, Colin S. Sheehan, Mete Emir Özgürses, Darby Agovino, Grace Croley, Lindsey N Dzierozynski, Chufan Cai, Leah M Ziolkowski, Smit A Patel, , Alexander Muir
The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.
bioRxiv · Mar 10, 2025Cancer Biology