Author

Darby Agovino

University of ChicagoORCID 0000-0002-6543-4235Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alexander MuiriD· 2 shared Colin S. SheehaniD· 2 shared Grace Croley· 2 shared Guillaume CognetiD· 2 shared Hardik ShahiD· 2 shared Kay F. MacleodiD· 2 shared Mumina SadullozodaiD· 2 shared Patrick B. JonkeriD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCancer Biology

Alexander MuirORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 4, 2025

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Colin S. Sheehan, Lyndon Hu, Guillaume Cognet…·Alexander Muir

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

DOI 10.1101/2025.09.04.673818

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivMar 10, 2025

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

Patrick B. Jonker, Mumina Sadullozoda, Guillaume Cognet…·Alexander Muir

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

1 citation

humanmetabolomics

𝕏 PostBluesky