Author

Grace Croley

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alexander MuiriD· 2 shared Colin S. SheehaniD· 2 shared Darby AgovinoiD· 2 shared Guillaume CognetiD· 2 shared Hardik ShahiD· 2 shared Kay F. MacleodiD· 2 shared Mumina SadullozodaiD· 2 shared Patrick B. JonkeriD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCancer Biology

Alexander MuirORCID

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2 papers

Recent·Most cited

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Colin S. Sheehan, Lyndon Hu, Guillaume Cognet, Grace Croley, Thao Trang Nguyen, Anika T. Thomas-Toth, Darby Agovino, Patrick B. Jonker, Mumina Sadullozoda, Leah M. Ziolkowski, James K. Martin, Alica K. Michels, Ranya Dano, Mohammed A. Khan, Rasangi Perera, , Alexander Muir

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

bioRxiv · Sep 4, 2025 · PreprintCancer Biology

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

Patrick B. Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J Apiz Saab, Kelly H Sokol, Vin‐Cent Wu, Deepa Kumari, Colin S. Sheehan, Mete Emir Özgürses, Darby Agovino, Grace Croley, Lindsey N Dzierozynski, Chufan Cai, Leah M Ziolkowski, Smit A Patel, , Alexander Muir

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

bioRxiv · Mar 10, 2025Cancer Biology