PhysiologybioRxivPreprint
Post-transcriptional regulation by the CCR4-NOT deadenylase complex maintains redox homeostasis in insulin biosynthesis in mouse pancreatic β cells
Akiko Yanagiya, Patrick N. Stoney, Yuki Tara…·Tadashi S. Yamamoto
The paper shows that CNOT7 deletion in mouse pancreatic β cells reduces insulin content and secretion by impairing proinsulin conversion, through reduced PRDX4 and increased CNOT8 binding to Prdx4 mRNA via MSI2.
DOI 10.1101/2024.06.26.599433