Guillaume Varès

This study shows that medical diagnostic radiation promotes colon carcinogenesis in mice with Apc and Kras mutations, especially during early tumor initiation.

The paper shows that CNOT7 deletion in mouse pancreatic β cells reduces insulin content and secretion by impairing proinsulin conversion, through reduced PRDX4 and increased CNOT8 binding to Prdx4 mRNA via MSI2.