James J. Lee

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

This study shows that inhibiting PTPN1/2 enhances alveolar macrophage anti-metastatic activity through IFN-gamma-STAT1 signaling, offering a therapeutic strategy for metastasis.

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The paper uses structural equation modeling on UK Biobank data to investigate the genetic basis of neuroticism, finding that significant variants are associated with brain-expressed genes and fear-related behaviors in mice.

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

This paper evaluates LD Score regression's ability to estimate confounding and genetic correlations in GWAS, showing it can produce unbiased or conservative estimates under various conditions.

The paper estimates genetic correlations between antisocial behavior and life history traits using GWAS data, finding positive and negative associations with reproductive output and delayed reproductive onset, respectively.

MTAG improves GWAS results by combining summary statistics across traits, increasing significant loci and enhancing polygenic score variance.

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.