Sung Ho Jung

Comprehensive Genetic Profiling of Sensorineural Hearing Loss Using an Integrative Diagnostic Approach

This study uses whole-genome sequencing and functional assays to improve genetic diagnosis of sensorineural hearing loss, achieving a 55.6% diagnostic yield through comprehensive genomic profiling.

Confirmatory insights into ELMOD3-associated autosomal dominant non-syndromic hearing loss

The paper identifies a novel ELMOD3 variant causing autosomal dominant hearing loss and shows its pathogenicity through structural and functional analyses.

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

This study uses base editing to correct a mutation causing hearing loss in a humanized mouse model, restoring hearing function and gene expression.

Adenine base editing corrects point mutation in mitochondrial single-stranded binding protein (SSBP1) to improve mitochondrial function

This study corrects a SSBP1 mutation using adenine base editors, improving mitochondrial function but with trade-offs between editing efficacy and off-target risks.