Elke Leysen

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

The paper identifies VCAM1 as an astrocytic regulator of hippocampal synapse development through cross-modal analysis combining single-cell spatial transcriptomics and protein-level profiling.

The paper uses an intrabody-guided proximity-labeling strategy to map postsynaptic proteomes in hippocampal CA1 pyramidal neurons and identifies early synaptic remodeling in an Alzheimer's disease mouse model.

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

The paper compares enhancer codes of cell types between mammalian neocortex and avian pallium using deep learning, finding higher divergence in excitatory neurons than other cell types.

The paper identifies distinct synaptic protein signatures and disease vulnerabilities in L5 IT and PT neurons, with autism risk genes enriched in L5 IT neurons.