Gabriele Marcassa

Intrabody-guided synapse proteomics defines pyramidal neuron input architecture and uncovers early remodeling in a mouse model of Alzheimer's disease

The paper uses an intrabody-guided proximity-labeling strategy to map postsynaptic proteomes in hippocampal CA1 pyramidal neurons and identifies early synaptic remodeling in an Alzheimer's disease mouse model.

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

Synaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons

The paper identifies distinct synaptic protein signatures and disease vulnerabilities in L5 IT and PT neurons, with autism risk genes enriched in L5 IT neurons.

HyDrop: droplet-based scATAC-seq and scRNA-seq using dissolvable hydrogel beads

HyDrop is a droplet microfluidic platform for scATAC-seq and scRNA-seq that improves throughput and sensitivity while reducing cost.