Keimpe D. B. Wierda

A subtype-specific gene regulatory program controls differential circuit integration of deep CA3 pyramidal neurons

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

Multimodal profiling and intersectional genetics reveal CA1 border inhibitory neuron diversity and postnatal emergence of retrosplenial connectivity

The paper identifies molecular and developmental diversity in CA1 border inhibitory neurons and shows their postnatal emergence of retrosplenial connectivity.

Intracortical bipolar stimulation allows selective activation of neuronal populations in the cortex

This study shows that bipolar intracortical stimulation selectively activates distinct neural populations, increasing addressable clusters by up to 9-fold compared to monopolar stimulation.

Extracellular neuroligin-ICAM5 coupling drives dendritic growth via actin remodeling

This study identifies ICAM5 as a neuroligin interactor that drives dendritic growth through actin remodeling by sustaining PAK-Cofilin signaling.

Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

MyeliMAP: Studying Oligodendrocyte Function in Brain Networks

MyeliMAP models human CNS myelination using hPSC-derived neurons and oligodendrocytes in a microfluidic platform, showing enhanced action potential conduction and stabilized network activity.

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

Presynaptic Release Probability Determines the Need for Sleep

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons

This study identifies LRRC37B as a human-specific gene that modulates neuronal excitability by interacting with voltage-gated sodium channels in cortical pyramidal neurons.

Corticotropin-Releasing Factor Induces Functional And Structural Synaptic Remodelling In Acute Stress

This study shows CRF rapidly alters synaptic function and structure in hippocampal CA1 neurons during acute stress, enhancing synaptic communication and memory consolidation.

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer's Disease

This study identifies impaired MCH-system function in AD models and patients, disrupting synaptic downscaling and neuronal activity stability.

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

The paper identifies IgSF8 as a regulator of hippocampal CA3 microcircuit development by analyzing cell-surface protein composition and synaptic interactions.

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function

This study identifies SorCS1's role in maintaining axonal surface polarization of neurexin by regulating its trafficking and endosomal sorting.