Jeroen Vandensteen

A subtype-specific gene regulatory program controls differential circuit integration of deep CA3 pyramidal neurons

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

Extracellular neuroligin-ICAM5 coupling drives dendritic growth via actin remodeling

This study identifies ICAM5 as a neuroligin interactor that drives dendritic growth through actin remodeling by sustaining PAK-Cofilin signaling.

Intrabody-guided synapse proteomics defines pyramidal neuron input architecture and uncovers early remodeling in a mouse model of Alzheimer's disease

The paper uses an intrabody-guided proximity-labeling strategy to map postsynaptic proteomes in hippocampal CA1 pyramidal neurons and identifies early synaptic remodeling in an Alzheimer's disease mouse model.

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells

The paper identifies a dynamic gene regulatory code in hippocampal granule cells that orchestrates synapse development through sequential regulation of transcription factors and target genes.

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium

The paper compares enhancer codes of cell types between mammalian neocortex and avian pallium using deep learning, finding higher divergence in excitatory neurons than other cell types.

Synaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons

The paper identifies distinct synaptic protein signatures and disease vulnerabilities in L5 IT and PT neurons, with autism risk genes enriched in L5 IT neurons.