Author

Sebastien M. Joruiz

National Institutes of HealthORCID 0000-0002-5613-2665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Curtis C. HarrisiD· 2 shared Delphine LissaiD· 2 shared Izumi HorikawaiD· 2 shared James IngleseiD· 1 shared Jessica A. BeckiD· 1 shared Kyra UngerleideriD· 1 shared Natalia von MuhlineniD· 1 shared Patricia K. DranchakiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

Curtis C. HarrisORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 28, 2025

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells

Sebastien M. Joruiz, Delphine Lissa, Natalia von Muhlinen…·Curtis C. Harris

This study shows that celastrol and AZD1981 increase Δ133p53 levels and reduce senescence and IL-6 secretion in HGPS-derived fibroblasts, independent of progerin levels.

DOI 10.1101/2025.07.28.667224

humanproteomics

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NeurosciencebioRxivMay 17, 2021

Δ133p53α Protects Human Astrocytes from Amyloid-Beta Induced Senescence and Neurotoxicity

Kyra Ungerleider, Jessica A. Beck, Delphine Lissa…·Curtis C. Harris

This paper shows that Δ133p53α protects human astrocytes from amyloid-beta-induced senescence and neurotoxicity by preventing DNA damage and SASP.

24 citations

humanexperimental assay

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