Patricia K. Dranchak

Chemoselective Halogenation of Premarineosin A for Next-Generation Antimalarial Development

The paper reports chemoselective halogenation of Premarineosin A, yielding analogs with retained antiplasmodial activity against both sensitive and resistant Plasmodium falciparum strains.

Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells

This study shows that celastrol and AZD1981 increase Δ133p53 levels and reduce senescence and IL-6 secretion in HGPS-derived fibroblasts, independent of progerin levels.

A Differential Ion Mobility Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug Targets

This paper introduces DAEMS, a system combining ion mobility and acoustic ejection mass spectrometry for high throughput screening of isomerization-mediated enzyme drug targets.

qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data

The paper introduces qHTSWaterfall, a 3D visualization tool for qHTS data, enabling the plotting of concentration-response curves with EC50 and Hill slope parameters.