The paper develops multi-regional gastric assembloids from patient-derived organoids to model parietal cell maturation and antral foveolar hyperplasia in genetic disorders.

Nature Biomedical Engineering · Jan 23, 2026Peer-reviewedCell Biology

Mapping the anatomical and transcriptional landscape of early human fetal ovary development

Sinead Mary McGlacken-Byrne, Ignacio del Valle, Theodoros A. Xenakis, Ian C. Simcock, Jenifer P. Suntharalingham, Federica Buonocore, Berta Crespo, Nadjeda Moreno, Danielle Liptrot, Paola Niola, Tony Brooks, Gerard S. Conway, Mehul Dattani, Owen John Arthurs, Nita Solanky, John C. Achermann

This study maps the anatomical and transcriptional changes in human fetal ovaries during development using single-nuclei RNA sequencing and other techniques, identifying novel pathways and regulators.

bioRxiv · Sep 26, 2023 · PreprintGenomics

A cell atlas of human adrenal cortex development and disease

Ignacio del Valle, Matthew D. Young, Gerda Kildisiute, Olumide Kayode Ogunbiyi, Federica Buonocore, Ian C. Simcock, Eleonora Khabirova, Berta Crespo, Nadjeda Moreno, Tony Brooks, Paola Niola, Katherine Swarbrick, Jenifer P. Suntharalingham, Sinead Mary McGlacken-Byrne, Owen John Arthurs, , John C. Achermann

This study creates a cell atlas of human adrenal cortex development using multi-omics approaches, revealing key developmental processes and potential therapeutic implications.

JCI Insight · Jul 19, 2023Peer-reviewedDevelopmental Biology