Tony Brooks

p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells

This study shows that p63 regulates stem cell function in human airway basal cells and declines with age, contributing to functional decline and reduced regenerative capacity.

The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development

The paper analyzes the transcriptomic differences in 45,X tissues compared to 46,XX and 46,XY controls during early human fetal and placental development, identifying gene expression changes associated with Turner syndrome.

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

This study compares metagenomics and targeted approaches for virus detection, finding that targeted methods improve sensitivity while untargeted ONT offers better specificity.

Sex differences in early human fetal brain development

This study analyzes transcriptomic differences between 46,XY and 46,XX human fetal brain cortex samples to understand sex chromosome and hormone effects during early development.

Single-nucleus RNA-sequencing reveals novel potential mechanisms of ovarian insufficiency in 45,X Turner Syndrome

This study uses single-nucleus and bulk RNA sequencing to identify novel pathogenic mechanisms of ovarian insufficiency in Turner Syndrome, beyond X chromosome haploinsufficiency.

Mapping the anatomical and transcriptional landscape of early human fetal ovary development

This study maps the anatomical and transcriptional changes in human fetal ovaries during development using single-nuclei RNA sequencing and other techniques, identifying novel pathways and regulators.

A cell atlas of human adrenal cortex development and disease

This study creates a cell atlas of human adrenal cortex development using multi-omics approaches, revealing key developmental processes and potential therapeutic implications.