Colin Molloy

This study shows that M1 receptor phosphorylation is critical for contextual memory but not cued memory, and biased Gq signaling alone is insufficient for restoring contextual memory.

The paper identifies a subpopulation of M4 mAChR-expressing astrocytes that regulate locomotion and have a detrimental effect in murine prion disease.

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

This study shows that activating M1 muscarinic receptors with VU846 slows murine prion disease progression, reduces neuroinflammation, and preserves synaptic proteins.

The paper screens coronavirus proteins for innate immune suppression, finding SARS-CoV-2 proteins are more potent immune suppressors than other coronaviruses.