James M. Osborne

A mechanical model of multicellular remodelling in epithelial monolayers

This paper introduces a mechanical model to simulate subcellular and tissue remodelling in epithelial monolayers, showing how deformation history affects tissue recovery.

Quantifying biological heterogeneity in nano-engineered particle-cell interaction experiments

This study develops a mathematical model to quantify heterogeneity in particle-cell interaction experiments and identifies optimal experimental time points for accurate parameter estimation.

Open Benchmarking for Cell-Based Multiscale Models: Lessons from a Community Initiative

This paper presents a community-driven benchmarking initiative for cell-based multiscale models, highlighting variations in tool implementations and advocating for standardized benchmarks and interoperability.

Competing mechanisms for the buckling of an epithelial monolayer identified using multicellular simulation

The paper uses a multicellular simulation model to identify two competing buckling mechanisms in epithelial monolayers: stromal deformation and stromal separation.

An adaptive numerical method for multi-cellular simulations of tissue development

This paper reviews numerical methods for multi-cellular tissue simulations and introduces an adaptive time-stepping algorithm that improves efficiency and accuracy.

A rigid body framework for multi-cellular modelling

This paper introduces a rigid body framework for multi-cellular modelling using one-dimensional edges to represent cells, demonstrating its application in replicating established results and solving limitations of current models.

Comparing individual-based approaches to modelling the self-organization of multicellular tissues

The paper compares different cell-based modelling approaches for simulating multicellular tissue self-organization using a unified framework.