NeuroscienceJournal of Alzheimer s DiseasePeer-reviewed
Early astrocytic dysfunction is associated to mistuned synapses as well as anxiety and depressive-like behavior in the AppNL-F mouse model of Alzheimers disease
Benjamin Portal, Moa Södergren, Teo Parés i Borrell…·Maria Lindskog
The paper investigates early synaptic dysfunction and emotional behavior in AppNL-F mice, finding reactive astrocytes contribute to synaptic mistuning before Aβ plaques and are linked to depressive-like behavior.
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