Nicole G. Metzendorf

This study identifies Paralemmin-2 as a component of axon initial segments and nodes of Ranvier, showing its role in modulating the submembrane cytoskeleton and neuronal excitability.

This study engineered sialylation on a scFv-based therapeutic to reduce anti-drug antibodies but found no significant impact on immunogenicity or pharmacokinetics in mice.

This study identifies Paralemmin-1 as a regulator of the neuronal submembrane cytoskeleton MPS, showing it enhances periodicity and is essential for its structure and function.

The paper investigates early synaptic dysfunction and emotional behavior in AppNL-F mice, finding reactive astrocytes contribute to synaptic mistuning before Aβ plaques and are linked to depressive-like behavior.