Author

Doaa Higazy

University of CopenhagenORCID 0000-0002-5660-8088Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Oana CiofuiD· 2 shared Christian BrandtiD· 1 shared Claus MoseriD· 1 shared Ke-Chuan WangiD· 1 shared Lene BayiD· 1 shared Mara LohdeiD· 1 shared Mark Grevsen MartinetiD· 1 shared Mathias MiddelboeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Oana CiofuORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 19, 2026

Evolutionary Trajectories of Ciprofloxacin Resistance in P. aeruginosa Lung Biofilms: Mutation Dynamics, Metabolomic Shifts, and Collateral Sensitivity

Doaa Higazy, Ke-Chuan Wang, Lene Bay…·Oana Ciofu

This study tracks the evolution of ciprofloxacin resistance in P. aeruginosa biofilms, revealing metabolic shifts and collateral sensitivity to other antibiotics.

DOI 10.64898/2026.05.07.723426

mousebulk RNA-seq

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MicrobiologyMicroorganismsPeer-reviewedSep 12, 2024

Diversification of Pseudomonas aeruginosa biofilm populations under repeated phage exposures decreases the efficacy of the treatment

Mark Grevsen Martinet, Mara Lohde, Doaa Higazy…·Oana Ciofu

This study shows that repeated phage exposure to P. aeruginosa biofilms reduces phage efficacy due to genetic changes that confer resistance and tolerance.

13 citations

humanwhole-genome sequencing

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