Fan Tu

Robust and scalable single-molecule protein sequencing with fluorosequencing

This paper improves fluorosequencing by optimizing fluorophores, reducing dye interactions, and creating an end-to-end workflow, demonstrating its potential for high-sensitivity clinical proteomics.

Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells

The paper quantifies the relative rates of axonemal deployment for cilia beating machineries during the final stages of differentiation in Xenopus multiciliated cells.

Systematic discovery of endogenous human ribonucleoprotein complexes

The paper systematically identifies endogenous human ribonucleoprotein complexes using a proteomics method and provides a resource for studying RNA-associated protein complexes.

A phase separated organelle at the root of motile ciliopathy

The paper identifies phase-separated organelles called Dynein Assembly Particles in ciliated cells and links their dysfunction to a human genetic disease.

A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexes

The paper synthesizes over 9,000 mass spectrometry experiments to create hu.MAP, a comprehensive human protein complex map with improved accuracy and coverage of disease-associated proteins.