Elizabeth Theusch

This study shows that TMEM55B loss disrupts lipid metabolism by altering lipophagy and mitochondrial function, worsening MASLD in mice.

This paper develops an iPSC-based risk predictor for MASLD using lipid accumulation measurements and validates it across three cohorts with varying performance.

This study shows that TOMM40 knockdown in macrophages inhibits NLRP3 activation and increases LXR-β mediated cholesterol transporter gene expression, potentially reducing atherogenesis.

This study identifies MIR192 as a regulator of GLP-1 receptor expression, showing it improves statin-induced impairment of insulin secretion.

This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

The paper identifies ZNF335 as a gene modulating statin response by analyzing cell line transcriptomics and mouse models.