ImmunologybioRxivPreprint
TOMM40 Knockdown in Macrophages Inhibits Oxidized LDL-induced NLRP3 Activation and Promotes LXR-β Mediated Cholesterol Transporter Gene Expression
Sai S. Chelluri, Neil Victor Yang, Elizabeth Theusch, Ronald M. Krauss
This study shows that TOMM40 knockdown in macrophages inhibits NLRP3 activation and increases LXR-β mediated cholesterol transporter gene expression, potentially reducing atherogenesis.
DOI 10.1101/2025.07.01.662675