Benjamin A. Kelvington

This study shows that increased complement component 3 (C3) expression in 16p11.2 hemideletion mice leads to hyperactive behavior, which can be alleviated by C3a receptor inhibition.

This study identifies sex- and cell type-specific transcriptomic and behavioral effects of 16p11.2 hemideletion in mice, revealing distinct impacts on striatal circuits and locomotor behavior.

This study identifies three genes in the 16p11.2 region that replicate sex-specific striatal phenotypes of 16p11.2 hemi-deletion in mice through CRISPR/Cas9-generated 3g del/+ mice.