Ted G. Abel

This study identifies lysine crotonylation (Kcr) as an epigenetic regulator of long-term memory and glutamatergic neurotransmission, showing its role in gene expression and synaptic function.

This study identifies a subset of hippocampal CA1 pyramidal neurons that are selectively reactivated by repeated sleep deprivation and shows associated molecular changes.

This study shows that increased complement component 3 (C3) expression in 16p11.2 hemideletion mice leads to hyperactive behavior, which can be alleviated by C3a receptor inhibition.

This study identifies cell-type- and region-specific transcriptional changes in non-neuronal cells of the mouse hippocampus and prefrontal cortex following acute sleep deprivation.

This study identifies lncRNA Cerox1 as a regulator of mitochondrial complex I activity and memory consolidation following sleep deprivation.

This study uses TRAP to identify neuronal circuits involved in acute seizures during TMEV infection in mice, finding increased tdTomato expression in multiple brain regions.

This study uses machine learning to define the transcriptomic architecture of the human cerebral cortex, revealing a multi-resolution organization and identifying core regions linked to higher cognitive functions.

This study identifies sex- and cell type-specific transcriptomic and behavioral effects of 16p11.2 hemideletion in mice, revealing distinct impacts on striatal circuits and locomotor behavior.

This study investigates how different PDE4A isoforms affect cAMP-dependent long-term potentiation (LTP), finding that PDE4A5 specifically impairs TBS-LTP through its unique N-terminus.

This study identifies three genes in the 16p11.2 region that replicate sex-specific striatal phenotypes of 16p11.2 hemi-deletion in mice through CRISPR/Cas9-generated 3g del/+ mice.

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.

The paper shows that GADD34, an Integrated Stress Response effector, is used by neurons to enhance eIF2-dependent translation in response to BDNF stimulation.

This study uses spatial transcriptomics to show that sleep deprivation causes region-specific gene expression changes in the brain, with the hippocampus showing the most significant alterations.

This study uses spatial transcriptomics to identify distinct gene expression signatures in hippocampal subregions during memory consolidation and shows their functional relevance.

This study identifies the gene expression changes in the human brain following electrical stimulation, revealing non-neuronal cell involvement and a conserved gene signature.

Experiments across four laboratories found that arbaclofen rescued cognitive deficits in mouse models of 16p11.2 deletion, without sedation or significant off-target behavioral effects.

This study shows that increasing cAMP levels in hippocampal neurons during sleep deprivation prevents deficits in long-term potentiation, indicating cAMP signaling mediates sleep loss effects on synaptic plasticity.

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.

This study shows that POPDC1 knockout mice have enhanced hippocampal long-term potentiation, suggesting POPDC1 modulates cAMP signaling in synaptic plasticity.

This study identifies 1,146 dysregulated genes in the hippocampus following acute sleep deprivation, revealing distinct transcriptomic changes in RNA splicing, cell adhesion, and synaptic processes.

This study shows that sleep deprivation reduces specific spine types on certain dendritic branches in CA1 neurons, but not others, suggesting branch-specific effects on structural plasticity.

This study investigates fear conditioning deficits in Pcdh10+/- mice, finding male-specific impairments across ages and female-specific deficits in adults.

This study shows that CREB is necessary in forebrain neurons for maintaining wakefulness but not in the locus coeruleus.

The paper shows that translin/trax is required for a specific form of hippocampal synaptic plasticity dependent on postsynaptic PKA, but not for presynaptic PKA-dependent plasticity.

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

The paper identifies clinically relevant genetic dysfunction in ASD risk genes by analyzing whole-exome data from 2,381 individuals, finding associations between specific variants and cognitive symptoms.