Yann S. Vanrobaeys

Lysine Crotonylation Acts as an Epigenetic Switch for Glutamate Neurotransmission and Spatial Memory

This study identifies lysine crotonylation (Kcr) as an epigenetic regulator of long-term memory and glutamatergic neurotransmission, showing its role in gene expression and synaptic function.

Cell-specific effects of acute sleep deprivation on transcriptomic signatures of non-neuronal cells in the mouse hippocampus and prefrontal cortex

This study identifies cell-type- and region-specific transcriptional changes in non-neuronal cells of the mouse hippocampus and prefrontal cortex following acute sleep deprivation.

Oxidative Stress and Interferon Signaling Drive Differential Pathogenesis of Ancestral and Contemporary Zika Viruses in Human Cerebral Organoids

This study compares pathogenesis of ancestral and contemporary Zika viruses in human cerebral organoids, finding differential signaling responses and identifying ROS imbalance as a key driver, which is mitigated by Trolox.

A chromosome region linked to neurodevelopmental disorders acts in distinct neuronal circuits in males and females to control locomotor behavior

This study identifies sex- and cell type-specific transcriptomic and behavioral effects of 16p11.2 hemideletion in mice, revealing distinct impacts on striatal circuits and locomotor behavior.

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders

This study identifies three genes in the 16p11.2 region that replicate sex-specific striatal phenotypes of 16p11.2 hemi-deletion in mice through CRISPR/Cas9-generated 3g del/+ mice.

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.

Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation

This study uses spatial transcriptomics to show that sleep deprivation causes region-specific gene expression changes in the brain, with the hippocampus showing the most significant alterations.

Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

This study uses spatial transcriptomics to identify distinct gene expression signatures in hippocampal subregions during memory consolidation and shows their functional relevance.

The gene expression signature of electrical stimulation in the human brain

This study identifies the gene expression changes in the human brain following electrical stimulation, revealing non-neuronal cell involvement and a conserved gene signature.

Endoplasmic Reticulum Chaperone Genes Encode Effectors of Long-Term Memory

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.