Marie E. Gaine

Sub-Chronic Chlorpyrifos Exposure Leads to Epigenetic and Sex-Specific Behavioral Changes in Adult Mice

This study shows that sub-chronic chlorpyrifos exposure causes sex-specific behavioral and epigenetic changes in adult mice, with female-specific effects independent of AChE activity and DNA methylation.

Suicidality phenotypes reflect both shared and distinct genetic factors

This study identifies shared and distinct genetic factors underlying suicidality phenotypes using GWAS and structural equation modelling.

Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model

This study shows that increased complement component 3 (C3) expression in 16p11.2 hemideletion mice leads to hyperactive behavior, which can be alleviated by C3a receptor inhibition.

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders

This study identifies three genes in the 16p11.2 region that replicate sex-specific striatal phenotypes of 16p11.2 hemi-deletion in mice through CRISPR/Cas9-generated 3g del/+ mice.

16p11.2 Microduplication is Associated with Lobule-Specific Abnormalities in Cerebellar Structure and Function

This study identifies lobule VI-specific structural and functional cerebellar abnormalities in 16p11.2 microduplication mice, linking them to learning impairments and neuropsychiatric disorder symptoms.

Cerebellar Morphological Differences in Bipolar Disorder Type I

This study finds smaller cerebellar cortex volumes in bipolar disorder type I patients, with medication use potentially influencing cerebellar structure.

Altered hippocampal transcriptome dynamics following sleep deprivation

This study identifies 1,146 dysregulated genes in the hippocampus following acute sleep deprivation, revealing distinct transcriptomic changes in RNA splicing, cell adhesion, and synaptic processes.

The CBP KIX domain regulates long-term memory and circadian activity

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.