Karen M. Arndt

This study shows that Glc7/PP1 dephosphorylates Spt5 to dislodge the Paf1 complex from RNAPII, enabling transcription termination in yeast.

The paper analyzes the evolutionary patterns of ten TEF orthologs across eukaryotes, showing their conservation in the last common ancestor and clade-specific variations.

ERC2.0 improves functional interaction prediction across large phylogenies by enhancing algorithm speed, normalization, and statistical power.

This study investigates the direct and indirect roles of Paf1C subunits in transcription elongation, splicing, and histone modifications in yeast using genetic and sequencing approaches.

The paper identifies how the Paf1 complex subunit Rtf1 interacts with Rad6 to stimulate H2B ubiquitylation, revealing a conserved interface that guides substrate specificity during transcription.

The paper identifies a direct interaction between Cdc73 and Spt6, showing Spt6 is required for Paf1C recruitment to active genes in yeast.

The paper identifies a genetic interaction between the Hda1C histone deacetylase and the H2B ubiquitylation pathway in regulating chromatin structure during transcription elongation in yeast.

MutantHuntWGS is a pipeline for analyzing Saccharomyces cerevisiae whole-genome sequencing data, identifying causal variants and providing reproducible results through containerization.

The paper identifies the nucleosome DNA entry-exit site as critical for transcription termination in yeast by showing that mutations affecting this site lead to transcriptional readthrough.

The paper identifies direct interactions between the nucleosome acidic patch and Paf1 and FACT complex subunits, showing their role in chromatin architecture and transcription elongation.

This study investigates the role of the Paf1 complex in regulating the transcriptome of Saccharomyces cerevisiae, revealing its impact on both coding and noncoding transcripts through transcriptional and post-transcriptional mechanisms.