Author

Margaret K. Shirra

University of PittsburghORCID 0000-0002-7526-1665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Karen M. ArndtiD· 4 shared Mitchell A. EllisoniD· 2 shared A Elizabeth HildrethiD· 1 shared Brendan M. McShaneiD· 1 shared Christine E. CucinottaiD· 1 shared Eleanor M. Kerr· 1 shared Fei Fang· 1 shared Hannah G. Marvil· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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10 top collaborators · 19 mutual co-author links

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4 shared papersMolecular Biology

Karen M. ArndtORCID

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4 papers

Recent·Most cited

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes

Sarah A. Tripplehorn, Santana M. Lardo, Margaret K. Shirra, Hannah G. Marvil, Sarah J. Hainer, Karen M. Arndt

Nucleic Acids Research · Aug 6, 2025Peer-reviewedMolecular Biology

Spt6 directly interacts with Cdc73 and is required for Paf1C recruitment to active genes

Mitchell A. Ellison, Matthew S Blacksmith, Sanchirmaa Namjilsuren, Margaret K. Shirra, Rachel A. Schusteff, Eleanor M. Kerr, Fei Fang, Yufei Xiang, Yi Shi, Karen M. Arndt

The paper identifies a direct interaction between Cdc73 and Spt6, showing Spt6 is required for Paf1C recruitment to active genes in yeast.

bioRxiv · May 4, 2022 · PreprintMolecular Biology

Opposing functions of the Hda1 complex and histone H2B mono-ubiquitylation in regulating cryptic transcription initiation in Saccharomyces cerevisiae

Margaret K. Shirra, Rachel A. Kocik, Mitchell A. Ellison, Karen M. Arndt

The paper identifies a genetic interaction between the Hda1C histone deacetylase and the H2B ubiquitylation pathway in regulating chromatin structure during transcription elongation in yeast.

G3 Genes Genomes Genetics · Aug 31, 2021Peer-reviewedMolecular Biology

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

Christine E. Cucinotta, A Elizabeth Hildreth, Brendan M. McShane, Margaret K. Shirra, Karen M. Arndt

The paper identifies direct interactions between the nucleosome acidic patch and Paf1 and FACT complex subunits, showing their role in chromatin architecture and transcription elongation.

Nucleic Acids Research · Jun 11, 2019Peer-reviewedMolecular Biology