William N. Grimes

A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa

The paper tests a drug to reduce noise in retinal circuits of mice with retinitis pigmentosa, finding it preserves visual sensitivity while decreasing circuit noise.

The retina's neurovascular unit: Mueller glial sheaths and neuronal contacts

This study investigates the structure and function of Muller glial sheaths in the retina's vascular layers, revealing compartmentalized interactions between glia and vessels.

Rod-cone signal interference in the retina shapes perception in primates

The paper links retinal circuit processing of rod and cone signals in non-human primates to perceptual phenomena, identifying mechanisms that explain flicker insensitivity.

Dendro-somatic synaptic inputs to ganglion cells violate receptive field and connectivity rules in the mammalian retina

The paper identifies a retinal circuit where A2 amacrine cells inhibit OFF ganglion cells in the ON layer, contradicting established connectivity and receptive field rules.

A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia

The paper identifies a new inhibitory retinal amacrine cell type, MAC, that forms direct electrical and chemical synapses with Müller glia, revealing neuron-glia coupling in the mammalian retina.

Rod signaling in primate retina: range, routing and kinetics

The paper shows that rod signals in primate retina use a single pathway regardless of light level, contrasting with mouse retina, and identifies light-level-dependent speeding of signals from rods themselves.