Author

Luise Butthof

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

Darjus Felix TschaharganehiD· 3 shared Lena Wendler-Link· 3 shared Hendrik WiethoffiD· 2 shared Lio Böse· 2 shared Marco BreinigiD· 2 shared Peter SchirmacheriD· 2 shared Agnieszka SeretnyiD· 1 shared Alexander Scheiter· 1 shared

Activity by Year

2025-2025 · peak 3/yr

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10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

Darjus Felix TschaharganehORCID

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3 papers

Recent·Most cited

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progression

Olatunji Oluwole Gege, Agnieszka Seretny, Luise Butthof, Long Pan, Lena Wendler-Link, Leonardo Traini, Lio Boese, Sabrina Neuhaeuser, Alexander Scheiter, Danijela Heide, Christian Luechtenborg, Britta Bruegger, Diego Calvisi, Mathias Heikenwaelder, Jessica Zucman‐Rossi, , Darjus Felix Tschaharganeh

This study shows BAP1 regulates liver homeostasis and tumor suppression by modulating ER stress and DDIT3 expression in response to metabolic stress.

bioRxiv · Nov 6, 2025 · PreprintCancer Biology

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers

Sonia Jiménez Vázquez, Christos Patsis, Mara Mitstorfer, Melanie Grimm, Luise Butthof, Lena Wendler-Link, Lio Böse, Hendrik Wiethoff, Ilse Hofmann, Kai Breuhahn, Thomas Longerich, Matthias M. Gaida, Peter Schirmacher, Judith Feucht, Marco Breinig, Darjus Felix Tschaharganeh

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

bioRxiv · Sep 17, 2025 · PreprintCancer Biology

Integrated combinatorial functional genomics and spatial transcriptomics of tumors decodes genotype to phenotype relationships

Marco Breinig, Artem Lomakin, Elyas Heidari, Michael A. Ritter, Gleb D. Rukhovich, Lio Böse, Luise Butthof, Lena Wendler-Link, Hendrik Wiethoff, Tanja Poth, Felix Sahm, Peter Schirmacher, Oliver Stegle, Moritz Gerstung, Darjus Felix Tschaharganeh

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

Nature Biomedical Engineering · Jul 28, 2025Peer-reviewedCancer Biology