Author

Ansley M. Roche

Yale Cancer CenterORCID 0000-0002-5696-3020Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Barbara Ann BurtnessiD· 1 shared Benjamin Schiff· 1 shared Cindy YangiD· 1 shared Dejian ZhaoiD· 1 shared Elizabeth B. PerryiD· 1 shared Erica A. GolemisiD· 1 shared Gary M. KupferiD· 1 shared Hongyu ZhaoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Barbara Ann BurtnessORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintMay 28, 2025

AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

Jong Woo Lee, Jackie Shi, Julian Barrantes…·Barbara Ann Burtness

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

DOI 10.1101/2025.05.28.656693

humanexperimental assay

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