Author

Gary M. Kupfer

Georgetown UniversityORCID 0000-0002-3988-2894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:synaptic & neural circuits· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alan AshworthiD· 1 shared Alexander MarsoniD· 1 shared Amy L. PutnamiD· 1 shared Andrea L. Ferris· 1 shared Andrew P. MayiD· 1 shared Ansley M. RocheiD· 1 shared Antoni RibasiD· 1 shared Barbara Ann BurtnessiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Alan AshworthORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 28, 2025

AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

Jong Woo Lee, Jackie Shi, Julian Barrantes…·Barbara Ann Burtness

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

DOI 10.1101/2025.05.28.656693

humanexperimental assay

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GeneticsNaturePeer-reviewedJul 1, 2018

Reprogramming human T cell function and specificity with non-viral genome targeting

Theodore L. Roth, Cristina Puig-Saus, Ruby Yu…·Alexander Marson

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.

839 citationstop 1%

humanexperimental assay

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