Author

Jong Woo Lee

Yale Cancer CenterORCID 0000-0002-9080-9641Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Ansley M. RocheiD· 1 shared Barbara Ann BurtnessiD· 1 shared Benjamin Schiff· 1 shared Cindy YangiD· 1 shared Dejian ZhaoiD· 1 shared Elizabeth B. PerryiD· 1 shared Erica A. GolemisiD· 1 shared Gary M. KupferiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ansley M. RocheORCID

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1 paper

Recent·Most cited

AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

Jong Woo Lee, Jackie Shi, Julian Barrantes, Pratima Chaurasia, Sundong Kim, Sebastian Restrepo Cruz, Cindy Yang, Jianlei Gu, Hongyu Zhao, Dejian Zhao, Benjamin Schiff, Ansley M. Roche, Elizabeth B. Perry, Jeffrey P. Townsend, Gary M. Kupfer, , Barbara Ann Burtness

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

bioRxiv · May 28, 2025 · PreprintCancer Biology