Jorge Lira Ruas

This study examines how endurance exercise with reduced muscle glycogen affects substrate utilization and signaling in human muscle fibers, finding altered fatty acid metabolism and mTORC1-autophagy dynamics.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

The paper uses long-read mRNA sequencing to analyze PGC-1α transcripts in murine and human hearts, identifying novel isoforms and promoters regulated in ischemia and obesity.

The paper investigates how different PGC-1α isoforms regulate hepatic metabolism and apoptosis in response to inflammation, identifying distinct roles for PGC-11 and PGC-14.