Andrew Holmes

This study identifies a sperm-enriched tRFValCAC that regulates early embryonic mRNA splicing and preimplantation development through interactions with hnRNPAB.

The paper analyzes tRNA gene variation across 17 closely related mouse strains to understand evolutionary dynamics and identifies conserved and strain-specific tRNA features.

This study examines how low-protein and high-fat diets affect tRNA abundance and modifications in multiple mouse tissues using RNA mass spectrometry and OTTR-seq.

This study shows that epididymis-specific RNase A family genes are essential for fertility and regulate small RNA processing in sperm.

The paper proposes a standardized ontology for naming tRNA-derived RNAs based on molecular origin to improve inter-study comparisons.

tRAX is a tool for analyzing tRNAs and tRNA-derived small RNAs, demonstrating its effectiveness in characterizing these transcriptomes in mouse tissues.

The paper predicts tRNA gene activity using sequence and genomic context features, finding strong correlations with G+C content and CpG density.