Valentina Paloschi

Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stability

This study uses Deep Visual Proteomics to analyze VSMC phenotypes in atherosclerotic plaques, finding spatially distinct phenotype distributions and a shift toward dedifferentiated states in unstable plaques.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

Topological Excitations govern Ordering Kinetics in Endothelial Cell Layers

The paper shows that topological defects and strings mediate ordering in endothelial cell layers, revealing an intermediate phase in their transition from disordered to ordered states.

The circular RNA Ataxia-telangiectasia mutated (cATM) regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

The paper identifies cATM as a circRNA upregulated in AAA tissue and patient-derived SMCs, showing its role in oxidative stress adaptation and potential as a biomarker for AAA.