Reinier Abraham Boon

Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia

This study identifies SNHG29 and IGF2BP1 as a lineage-specific oncogenic circuit in AMKL, showing their dependency and therapeutic vulnerability.

Advancing Nuclei Isolation from Frozen Human Heart for Single-Nucleus RNA Sequencing Applications

This paper presents a standardized nuclei isolation protocol for frozen human heart tissue and a downstream snRNA-seq analysis pipeline, improving yield and consistency in cardiac single-nucleus transcriptomic studies.

Leukocytes use endothelial membrane tunnels to extravasate the vasculature

The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

The circular RNA Ataxia-telangiectasia mutated (cATM) regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

The paper identifies cATM as a circRNA upregulated in AAA tissue and patient-derived SMCs, showing its role in oxidative stress adaptation and potential as a biomarker for AAA.

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

This study identifies NUDT6 as an antisense transcript of FGF2, showing that its silencing enhances smooth muscle cell survival and limits vascular disease progression.

The endothelial-specific LINC00607 mediates endothelial angiogenic function

This study identifies LINC00607 as an endothelial-specific lncRNA that supports angiogenic function by interacting with BRG1 to regulate chromatin accessibility and ERG target gene transcription.

The PNUTS-PP1 axis regulates endothelial aging and barrier function via SEMA3B suppression

This study identifies the PNUTS-PP1 axis as critical for endothelial aging and barrier function, showing that SEMA3B suppression mediates these effects.