Amal Zine El Aabidine

This study investigates how SETX mutations in ALS4 lead to RNA dysregulation and neuronal dysfunction through TGF-β signaling activation and R-loop metabolism disruption.

The paper shows ECM stiffness alters nuclear lamina composition and PRC2-mediated gene repression through changes in chromatin structure and motion.

The paper investigates how the nucleus integrates mechanoprotection and mechanosensing during EMT by analyzing spatial patterns of chromatin response to mechanical forces.

This study identifies G-quadruplexes as promoter elements that exclude nucleosomes and facilitate RNA polymerase II pausing.

This study shows that the transcription factor GAF acts as a stable mitotic bookmark during zygotic genome activation in Drosophila embryos, enabling rapid transcriptional activation after mitosis.

SAVAGE reconstructs individual haplotypes of intrahost viral strains without a reference genome, outperforming existing methods on simulated and real data.