Author

Karen J. Scott

University of LeedsORCID 0000-0002-5790-9579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adel SamsoniD· 2 shared Adam C. ConnoriD· 1 shared Alan A. MelcheriD· 1 shared Alyn L. CratchleyiD· 1 shared Amy Moran· 1 shared Andrew MacdonaldiD· 1 shared Darren James NewtoniD· 1 shared Elizabeth J. IlettiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Adel SamsonORCID

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2 papers

Recent·Most cited

Cancer BiologyCancersPeer-reviewedSep 22, 2026

The immune and genetic heterogeneity of Hepatocellular Carcinoma, with a focus on multifocal disease

Adam C. Connor, Leon Chang, Emma J. West…·Adel Samson

This study examines genetic and immune heterogeneity in HCC, finding significant discordance in genetic and immune profiles between multifocal tumours.

DOI 10.3390/cancers18193079

humanwhole-exome sequencing

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 23, 2024

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

Russell Hughes, Amy Moran, Karen J. Scott…·Stephen D. C. Griffin

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky