Marcel Kwiatkowski

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

The paper identifies TXNIP as a regulator of amino acid uptake during cellular quiescence by mediating endocytosis of the LAT1/SLC7A5 transporter.

GEMCAT - A new algorithm for gene expression-based prediction of metabolic alterations

GEMCAT predicts metabolic changes from transcriptomics or proteomics data and validates them with metabolomics, demonstrating its utility in human cell lines and inflammatory bowel disease patients.

Proteome coverage after simultaneous proteo-metabolome liquid-liquid extraction

This study compares proteome coverage and extraction efficiency of different solubilization agents in proteo-metabolome analysis using SPM-LLE and direct cell lysis.

Natural isotope correction improves analysis of protein modification dynamics

The paper introduces PICor, a tool for isotopologue correction in proteomics and metabolomics, demonstrating its importance for accurate analysis of protein modification dynamics.

Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease

The paper uses a fibroblast-specific genome-scale model to identify metabolic imbalances in Refsum disease, highlighting amino acid metabolism changes.