Justina Clarinda Wolters

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

This study shows that cGAS-STING activation in alveolar epithelial cells impairs regeneration and differentiation in response to cigarette smoke exposure.

This study uses proteomics to compare serum and liver samples from GSD Ia and Ib patients, identifying subtype-specific biomarkers and pathways linked to disease complications.

The paper profiles serum N-glycans in GSD Ia and Ib patients and controls, identifying subtype-specific glycomic alterations and potential biomarkers for disease subtyping and tumor surveillance.

The paper identifies fibroblast-derived osteoglycin as a key factor promoting epithelial cell repair and presents its active fragment as a potential therapeutic for lung diseases.

This paper develops targeted mass spectrometry assays to detect and quantify endogenous ORF1p and ORF2p proteins, demonstrating sensitive and robust quantitation of ORF2p for the first time.

This study identifies dual localization of mitochondrial carrier proteins Aac2 and Mir1 to peroxisomes and mitochondria in Hansenula polymorpha, revealing requirements for Pex3 and Pex19 in peroxisomal targeting.

This study shows that hepatic VPS35 deficiency disrupts lysosomal cholesterol metabolism, leading to increased cholesterol levels in plasma and liver.

This study successfully humanizes the entire glycolytic pathway in yeast, revealing conserved functions and context-dependent responses.

The paper uses a fibroblast-specific genome-scale model to identify metabolic imbalances in Refsum disease, highlighting amino acid metabolism changes.