Kathrin Thedieck

Collective parameter estimation of related models with an initial stability constraint

The paper introduces tools for parameter estimation of biochemical networks using stability constraints, validated on MTOR network data from breast cancer cells.

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

The paper identifies TXNIP as a regulator of amino acid uptake during cellular quiescence by mediating endocytosis of the LAT1/SLC7A5 transporter.

Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity

The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

GEMCAT - A new algorithm for gene expression-based prediction of metabolic alterations

GEMCAT predicts metabolic changes from transcriptomics or proteomics data and validates them with metabolomics, demonstrating its utility in human cell lines and inflammatory bowel disease patients.

Proteome coverage after simultaneous proteo-metabolome liquid-liquid extraction

This study compares proteome coverage and extraction efficiency of different solubilization agents in proteo-metabolome analysis using SPM-LLE and direct cell lysis.