Ist2 promotes lipid transfer by Osh6 via its membrane tethering and lipid scramblase activities
Alicia Fabbre, Camille Syska, Heitor Gobbi Sebinelli, Anna Cardinal, Maud Magdeleine, Noha Al-Qatabi, Juan Martín D’Ambrosio, Cédric Montigny, Guillaume Lenoir, Alenka Čopič, Guillaume Drin
This study shows that Osh6 requires Ist2 for efficient phosphatidylserine transfer between membranes, revealing a functional partnership between an LTP and a membrane tethering/scramblase protein.
Science Advances · Nov 14, 2025Peer-reviewedBiochemistry