Author

Daria Kotlarek

ORCID 0000-0002-5827-6347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1

Frequent Co-Authors

Alicja N. SkowroniD· 2 shared Daria Gajewska· 2 shared Igor H. WierzbickiiD· 2 shared Janusz WiśniewskiiD· 2 shared Karolina Maria GóreckaiD· 2 shared Magdalena Sypien· 2 shared Marta KlejnotiD· 2 shared Martyna W. PastokiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Alicja N. SkowronORCID

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2 papers

Recent·Most cited

Molecular BiologyChemMedChemPeer-reviewedApr 3, 2026

Ligand-induced Conformational Plasticity of the CTLH E3 Ligase Receptor GID4

Daria Kotlarek, Katarzyna Dudek, Bartosz Woźniak…·Michał Walczak

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

DOI 10.1002/cmdc.202500849

experimental assaydrug response / drug discovery

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Molecular BiologybioRxivPreprintJul 13, 2025

A Robust Crystallographic Platform for High-Throughput β-Catenin Ligand Discovery

Marta Klejnot, Alicja N. Skowron, Jaromir Szymański…·Michał Walczak

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.

DOI 10.1101/2025.07.13.663865

protein structureexperimental assay

𝕏 PostBluesky