Janusz Wiśniewski

The paper identifies distinct intrinsic sequence patterns between HIV-1 DNA and RNA across subtypes using a k-mer-based approach and presents a new tool for genomic analysis.

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

The paper identifies ABS-752, a molecular glue prodrug that degrades GSPT1 and NEK7 in HCC cells, showing potent in vitro and in vivo activity.

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.

This study investigates how HIV sense and antisense transcripts influence stochastic HIV transcription and reactivation through chromosomal and integration site-related fluctuations.

The paper identifies SARS-CoV-2 genetic markers associated with host domestication using a k-mer-based pipeline, revealing mutations and host-specific genomic patterns.