Marta Klejnot

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

The paper identifies ABS-752, a molecular glue prodrug that degrades GSPT1 and NEK7 in HCC cells, showing potent in vitro and in vivo activity.

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.