Daria Gajewska

Ligand-induced Conformational Plasticity of the CTLH E3 Ligase Receptor GID4

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC

The paper identifies ABS-752, a molecular glue prodrug that degrades GSPT1 and NEK7 in HCC cells, showing potent in vitro and in vivo activity.

A Robust Crystallographic Platform for High-Throughput β-Catenin Ligand Discovery

This paper develops a robust crystallographic platform for discovering β-catenin ligands through optimized protein production and screening methods.

Expression screen of TNFR1 R347A, MyD88, IRAK4 death domains in E. coli followed by purification and biophysical characterization of TNFR1 R347A death domain

The paper optimizes expression and characterizes the stability of TNFR1 R347A, MyD88, and IRAK4 death domains in E. coli.