Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling
Marc Expòsit, Mohamad H. Abedi, Aditya Krishnakumar, Shruti Jain, Ta-Yi Yu, Timothy R. Hercus, Divij Mathew, Sophie L. Gray-Gaillard, Zhijie Chen, William S. Grubbe, Andrew Favor, Winnie L. Kan, Thomas Schlichthaerle, Wei Chen, Michael W. Parker, , David A. Baker
This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.
bioRxiv · Oct 12, 2025 · PreprintSynthetic Biology